| Week | Scheduled | Matchup | Score | Status |
|---|---|---|---|---|
| 1 | Sunday Sep 7th 4:05pm | San Francisco 49ers @ Seattle Seahawks | 17 13 | FINAL |
| 2 | Sunday Sep 14th 1:00pm | San Francisco 49ers @ New Orleans Saints | 26 21 | FINAL |
| 3 | Sunday Sep 21st 4:25pm | Arizona Cardinals @ San Francisco 49ers | 15 16 | FINAL |
| 4 | Sunday Sep 28th 4:05pm | Jacksonville Jaguars @ San Francisco 49ers | 26 21 | FINAL |
| 5 | Thursday Oct 2nd 8:15pm | San Francisco 49ers @ Los Angeles Rams | 26 23 | FINAL/OT |
| 6 | Sunday Oct 12th 4:25pm | San Francisco 49ers @ Tampa Bay Buccaneers | 19 30 | FINAL |
| 7 | Sunday Oct 19th 8:20pm | Atlanta Falcons @ San Francisco 49ers | 10 20 | FINAL |
| 8 | Sunday Oct 26th 1:00pm | San Francisco 49ers @ Houston Texans | 15 26 | FINAL |
| 9 | Sunday Nov 2nd 1:00pm | San Francisco 49ers @ New York Giants | 34 24 | FINAL |
| 10 | Sunday Nov 9th 4:25pm | Los Angeles Rams @ San Francisco 49ers | 42 26 | FINAL |
| 11 | Sunday Nov 16th 4:05pm | San Francisco 49ers @ Arizona Cardinals | 41 22 | FINAL |
| 12 | Monday Nov 24th 8:15pm | Carolina Panthers @ San Francisco 49ers | 9 20 | FINAL |
| 13 | Sunday Nov 30th 1:00pm | San Francisco 49ers @ Cleveland Browns | 26 8 | FINAL |
| 14 | BYE | |||
| 15 | Sunday Dec 14th 4:25pm | Tennessee Titans @ San Francisco 49ers | 24 37 | FINAL |
| 16 | Monday Dec 22nd 8:15pm | San Francisco 49ers @ Indianapolis Colts | 48 27 | FINAL |
| 17 | Sunday Dec 28th 8:20pm | Chicago Bears @ San Francisco 49ers | 38 42 | FINAL |
| 18 | Saturday Jan 3rd 8:00pm | Seattle Seahawks @ San Francisco 49ers | 13 3 | FINAL |