| Week | Scheduled | Matchup | Score | Status |
|---|---|---|---|---|
| 1 | Sunday Sep 7th 8:20pm | Baltimore Ravens @ Buffalo Bills | 40 41 | FINAL |
| 2 | Sunday Sep 14th 1:00pm | Buffalo Bills @ New York Jets | 30 10 | FINAL |
| 3 | Thursday Sep 18th 8:15pm | Miami Dolphins @ Buffalo Bills | 21 31 | FINAL |
| 4 | Sunday Sep 28th 1:00pm | New Orleans Saints @ Buffalo Bills | 19 31 | FINAL |
| 5 | Sunday Oct 5th 8:20pm | New England Patriots @ Buffalo Bills | 23 20 | FINAL |
| 6 | Monday Oct 13th 7:15pm | Buffalo Bills @ Atlanta Falcons | 14 24 | FINAL |
| 7 | BYE | |||
| 8 | Sunday Oct 26th 1:00pm | Buffalo Bills @ Carolina Panthers | 40 9 | FINAL |
| 9 | Sunday Nov 2nd 4:25pm | Kansas City Chiefs @ Buffalo Bills | 21 28 | FINAL |
| 10 | Sunday Nov 9th 1:00pm | Buffalo Bills @ Miami Dolphins | 13 30 | FINAL |
| 11 | Sunday Nov 16th 1:00pm | Tampa Bay Buccaneers @ Buffalo Bills | 32 44 | FINAL |
| 12 | Thursday Nov 20th 8:15pm | Buffalo Bills @ Houston Texans | 19 23 | FINAL |
| 13 | Sunday Nov 30th 4:25pm | Buffalo Bills @ Pittsburgh Steelers | 26 7 | FINAL |
| 14 | Sunday Dec 7th 1:00pm | Cincinnati Bengals @ Buffalo Bills | 34 39 | FINAL |
| 15 | Sunday Dec 14th 1:00pm | Buffalo Bills @ New England Patriots | 35 31 | FINAL |
| 16 | Sunday Dec 21st 1:00pm | Buffalo Bills @ Cleveland Browns | 23 20 | FINAL |
| 17 | Sunday Dec 28th 4:25pm | Philadelphia Eagles @ Buffalo Bills | 13 12 | FINAL |
| 18 | Sunday Jan 4th 4:25pm | New York Jets @ Buffalo Bills | 8 35 | FINAL |