| Week | Scheduled | Matchup | Score | Status |
|---|---|---|---|---|
| 1 | Sunday Sep 7th 1:00pm | Miami Dolphins @ Indianapolis Colts | 8 33 | FINAL |
| 2 | Sunday Sep 14th 4:05pm | Denver Broncos @ Indianapolis Colts | 28 29 | FINAL |
| 3 | Sunday Sep 21st 1:00pm | Indianapolis Colts @ Tennessee Titans | 41 20 | FINAL |
| 4 | Sunday Sep 28th 4:05pm | Indianapolis Colts @ Los Angeles Rams | 20 27 | FINAL |
| 5 | Sunday Oct 5th 1:00pm | Las Vegas Raiders @ Indianapolis Colts | 6 40 | FINAL |
| 6 | Sunday Oct 12th 1:00pm | Arizona Cardinals @ Indianapolis Colts | 27 31 | FINAL |
| 7 | Sunday Oct 19th 4:05pm | Indianapolis Colts @ Los Angeles Chargers | 38 24 | FINAL |
| 8 | Sunday Oct 26th 4:25pm | Tennessee Titans @ Indianapolis Colts | 14 38 | FINAL |
| 9 | Sunday Nov 2nd 1:00pm | Indianapolis Colts @ Pittsburgh Steelers | 20 27 | FINAL |
| 10 | Sunday Nov 9th 9:30am | Atlanta Falcons @ Indianapolis Colts | 25 31 | FINAL/OT |
| 11 | BYE | |||
| 12 | Sunday Nov 23rd 1:00pm | Indianapolis Colts @ Kansas City Chiefs | 20 23 | FINAL/OT |
| 13 | Sunday Nov 30th 1:00pm | Houston Texans @ Indianapolis Colts | 20 16 | FINAL |
| 14 | Sunday Dec 7th 1:00pm | Indianapolis Colts @ Jacksonville Jaguars | 19 36 | FINAL |
| 15 | Sunday Dec 14th 4:25pm | Indianapolis Colts @ Seattle Seahawks | 16 18 | FINAL |
| 16 | Monday Dec 22nd 8:15pm | San Francisco 49ers @ Indianapolis Colts | 48 27 | FINAL |
| 17 | Sunday Dec 28th 1:00pm | Jacksonville Jaguars @ Indianapolis Colts | 23 17 | FINAL |
| 18 | Sunday Jan 4th 1:00pm | Indianapolis Colts @ Houston Texans | 30 38 | FINAL |