| Week | Scheduled | Matchup | Score | Status |
|---|---|---|---|---|
| 1 | Friday Sep 5th 8:00pm | Kansas City Chiefs @ Los Angeles Chargers | 21 27 | FINAL |
| 2 | Monday Sep 15th 10:00pm | Los Angeles Chargers @ Las Vegas Raiders | 20 9 | FINAL |
| 3 | Sunday Sep 21st 4:05pm | Denver Broncos @ Los Angeles Chargers | 20 23 | FINAL |
| 4 | Sunday Sep 28th 1:00pm | Los Angeles Chargers @ New York Giants | 18 21 | FINAL |
| 5 | Sunday Oct 5th 4:25pm | Washington Commanders @ Los Angeles Chargers | 27 10 | FINAL |
| 6 | Sunday Oct 12th 1:00pm | Los Angeles Chargers @ Miami Dolphins | 29 27 | FINAL |
| 7 | Sunday Oct 19th 4:05pm | Indianapolis Colts @ Los Angeles Chargers | 38 24 | FINAL |
| 8 | Thursday Oct 23rd 8:15pm | Minnesota Vikings @ Los Angeles Chargers | 10 37 | FINAL |
| 9 | Sunday Nov 2nd 1:00pm | Los Angeles Chargers @ Tennessee Titans | 27 20 | FINAL |
| 10 | Sunday Nov 9th 8:20pm | Pittsburgh Steelers @ Los Angeles Chargers | 10 25 | FINAL |
| 11 | Sunday Nov 16th 1:00pm | Los Angeles Chargers @ Jacksonville Jaguars | 6 35 | FINAL |
| 12 | BYE | |||
| 13 | Sunday Nov 30th 4:25pm | Las Vegas Raiders @ Los Angeles Chargers | 14 31 | FINAL |
| 14 | Monday Dec 8th 8:15pm | Philadelphia Eagles @ Los Angeles Chargers | 19 22 | FINAL/OT |
| 15 | Sunday Dec 14th 1:00pm | Los Angeles Chargers @ Kansas City Chiefs | 16 13 | FINAL |
| 16 | Sunday Dec 21st 1:00pm | Los Angeles Chargers @ Dallas Cowboys | 34 17 | FINAL |
| 17 | Saturday Dec 27th 4:30pm | Houston Texans @ Los Angeles Chargers | 20 16 | FINAL |
| 18 | Sunday Jan 4th 4:25pm | Los Angeles Chargers @ Denver Broncos | 3 19 | FINAL |