| Week | Scheduled | Matchup | Score | Status |
|---|---|---|---|---|
| 1 | Sunday Sep 7th 4:25pm | Detroit Lions @ Green Bay Packers | 13 27 | FINAL |
| 2 | Sunday Sep 14th 1:00pm | Chicago Bears @ Detroit Lions | 21 52 | FINAL |
| 3 | Monday Sep 22nd 8:15pm | Detroit Lions @ Baltimore Ravens | 38 30 | FINAL |
| 4 | Sunday Sep 28th 1:00pm | Cleveland Browns @ Detroit Lions | 10 34 | FINAL |
| 5 | Sunday Oct 5th 4:25pm | Detroit Lions @ Cincinnati Bengals | 37 24 | FINAL |
| 6 | Sunday Oct 12th 8:20pm | Detroit Lions @ Kansas City Chiefs | 17 30 | FINAL |
| 7 | Monday Oct 20th 7:00pm | Tampa Bay Buccaneers @ Detroit Lions | 9 24 | FINAL |
| 8 | BYE | |||
| 9 | Sunday Nov 2nd 1:00pm | Minnesota Vikings @ Detroit Lions | 27 24 | FINAL |
| 10 | Sunday Nov 9th 4:25pm | Detroit Lions @ Washington Commanders | 44 22 | FINAL |
| 11 | Sunday Nov 16th 8:20pm | Detroit Lions @ Philadelphia Eagles | 9 16 | FINAL |
| 12 | Sunday Nov 23rd 1:00pm | New York Giants @ Detroit Lions | 27 34 | FINAL/OT |
| 13 | Thursday Nov 27th 1:00pm | Green Bay Packers @ Detroit Lions | 31 24 | FINAL |
| 14 | Thursday Dec 4th 8:15pm | Dallas Cowboys @ Detroit Lions | 30 44 | FINAL |
| 15 | Sunday Dec 14th 4:25pm | Detroit Lions @ Los Angeles Rams | 34 41 | FINAL |
| 16 | Sunday Dec 21st 4:25pm | Pittsburgh Steelers @ Detroit Lions | 29 24 | FINAL |
| 17 | Thursday Dec 25th 4:30pm | Detroit Lions @ Minnesota Vikings | 10 23 | FINAL |
| 18 | Sunday Jan 4th 4:25pm | Detroit Lions @ Chicago Bears | 19 16 | FINAL |